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KMID : 1134820070360070832
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 7 p.832 ~ p.839
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Effects of Supplemental Agents Enhancing Calcium Absorption on Bioavailability of Starfish Calcium in Rats
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Lee Yeon-Sook
Moon Ji-Young
Jang Soo-Jung
Park Mi-Na
Park Hee-Yeon
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Abstract
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This study was conducted to investigate the bioavailability of starfish calcium with substances enhancing calcium absorption. Three week-old young female rats (Sprague-Dawley) were divided into 5 groups according to calcium sources and testing agents; calcium carbonate (C), starfish calcium (S), starfish calcium＋casein phosphopeptide (S-CPP), starfish calcium＋citrate-malate (S-CM), starfish calcium＋isoflavone (S-ISO), and were fed experimental diets containing AIN-93G based Ca (0.35% w/w) diet with CPP, CM and ISO for 6 weeks. Blood, femur, urine and feces samples were collected. There was no significant difference among groups in terms of growth and food intake. Serum Ca concentrations were normal in all 5 groups. Serum P concentrations and ALP activities were not significantly different among groups. Ca absorption and retention were significantly increased both in S-CPP and S-CM groups compared to C group (p＜0.05). P absorption was significantly higher in S-CPP group than in other groups. While the amount of soluble Ca of intestinal contents did not differ among groups, the amount of insoluble Ca was significantly lower in S-CPP, S-CM and S-ISO groups than in C and S groups. However, the weight, Ca and P concentrations of femur were not significantly different among groups. These results suggest that the addition of CPP and citrate-malate were more effective for enhancing the bioavailability, intestinal absorption and solubility of starfish calcium.
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KEYWORD
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starfish calcium, calcium bioavailability, casein phosphopeptide, citrate-malate, isoflavone
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